Multiple adverse drug reactions and genetic polymorphism testing: A case report with negative result.
Arellano AL, Martin-Subero M, Monerris M, LLerena A, Farré M, Montané E
Medicine Impact Factor: 5.723
PubMed Id: 29137046 Link a PubMed
Defects in drug metabolic pathways could explain why some patients have a history of multiple adverse drug reactions (ADR); therefore we aimed to analyze genetic polymorphisms in a patient with multiple ADR related to drugs with a common hepatic metabolic pathway through CYP2D6.A pharmacogenetic test was performed to assess the causative role of the CYP2D6 enzyme, but did not demonstrate a metabolic deficiency.Although negative results in the reported case; typing for cytochrome P450 isoenzyme polymorphisms could be a useful diagnostic tool in some patients with a history of multiple ADR.